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Generic Vitamin D3
Used for Vitamin D Deficiency
Used for Vitamin D Deficiency
Vitamin D3 (cholecalciferol) is an over-the-counter dietary supplement that's taken by mouth to raise vitamin D levels. It's for adults and children who aren't getting enough vitamin D through food or sunlight, or for people who've certain conditions that cause vitamin D deficiency, like liver or kidney problems. Vitamin D3 (cholecalciferol) is usually taken daily, but it's sometimes taken weekly, depending on the dose. Vitamin D3 (cholecalciferol) isn't known to cause any side effects if you're taking the recommended dose.
Reviewed by:
Kristianne Hannemann, PharmD
Allison Gourley, PharmD
Last reviewed on September 28, 2023
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What is Vitamin D3 (cholecalciferol) ?
What is Vitamin D3 (cholecalciferol) used for?
Low vitamin D levels
How Vitamin D3 (cholecalciferol) works
Vitamin D3 (cholecalciferol) is a dietary supplement that boosts your body's vitamin D levels when it's low.
Vitamin D is hormone that your body naturally makes. You can also get it through the foods you eat. Vitamin D very important to help your body work properly. For example, you need vitamin D to absorb calcium, which is important to keep your bones strong. In addition, you also need vitamin D for healthy muscles, nerves, and immune systems.
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Are you looking for information on vitamin D2 (ergocalciferol) instead?
Drug Facts
Common BrandsVitamin D3, Decalcitrol, Decara High Potency Vitamin D3, Enfamil D-Vi-Sol, D-Trol
Drug ClassDietary supplement
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
More on Vitamin D3 (cholecalciferol) essentials
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Avg retail price
$12.41
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What are the side effects of Vitamin D3 (cholecalciferol) ?
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
See Risks and Warnings.
Serious Side Effects
Contact your healthcare provider immediately if you experience any of the following.
Source:DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- High calcium level—increased thirst or amount of urine, nausea, vomiting, confusion, unusual weakness or fatigue, bone pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Loss of appetite
- Nausea
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Pros and cons of Vitamin D3 (cholecalciferol)
Pros
Raises vitamin D levels better than vitamin D2 (ergocalciferol)
Available over the counter
Comes in many different forms (e.g., liquid, gummies, tablets, capsules)
Available as a once-weekly, high-dose capsule (taken only if instructed by your provider)
Cons
Some forms of vitamin D3 (cholecalciferol) are animal-based, which can be a problem for vegetarians, vegans, and people of certain faiths.
Too much vitamin D can cause side effects that can last for months after stopping the supplement.
Can be easy to forget to take, since you can't feel vitamin D3 (cholecalciferol) working
Pharmacist tips for Vitamin D3 (cholecalciferol)
Only take high-dose (50,000 IU) vitamin D3 (cholecalciferol) if your provider tells you to do so. Most people don't need to take this much. Don't take more than instructed by your provider to avoid side effects, and be sure to get any ordered blood tests done on time.
Contact your provider if you notice an unexplainable loss of appetite, nausea, constipation, weight loss, weakness, general aches, or stiffness. These might be signs that you're taking too much vitamin D.
If you're using the liquid version of vitamin D3 (cholecalciferol) , use the medication dropper that comes with the package to measure each dose. If a dropper didn't come with your package, ask your pharmacy to provide you with one. Don't use household teaspoons to measure out your dose of vitamin D3 (cholecalciferol) , since these can cause you to take the wrong dose.
Make sure your providers have a list of all your medications and supplements you take on a regular basis, including those purchased over the counter. You might already be taking a product that includes vitamin D, and taking too much can lead to side effects.
More on Vitamin D3 (cholecalciferol) tips
Frequently asked questions about Vitamin D3 (cholecalciferol)
How much vitamin D3 (cholecalciferol) should I take daily?
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Check in with your provider to see if you need to start taking vitamin D3 (cholecalciferol) daily. Many people already get enough vitamin D through foods or sunlight and don't need to take a vitamin D3 (cholecalciferol) supplement. But if you need to start vitamin D3 (cholecalciferol) , your provider can recommend a dose based on your age, diet, and what health conditions you have. In general, healthy children and adults need 600 IU daily. But older adults age 70 years and older need 800 IU per day.
Can I take 5,000 IU of vitamin D3 (cholecalciferol) every day?
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Don't take 5,000 IU of vitamin D3 (cholecalciferol) every day unless your provider instructed you to do so. This dose is higher than the recommended dietary allowance (RDA) of vitamin D for adults and children; most people don't need to take this much vitamin D every day. Depending on what medical condition you have, your provider might recommend that you take a higher daily dose of vitamin D, but only for a limited period of time. Taking too much vitamin D for a long period of time can be harmful to your health.
Can you take too much vitamin D3 (cholecalciferol) ?
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Yes, it's possible to take too much vitamin D3 (cholecalciferol) . Taking higher-than-recommended doses of vitamin D3 (cholecalciferol) over long periods of time can cause symptoms such as confusion, vomiting, and muscle weakness. Ask your provider how much vitamin D is safe for you to take. Also, double check the ingredients on all of your supplements to make sure you're not taking more vitamin D than you're aware of; vitamin D3 (cholecalciferol) is a common ingredient in multivitamins. If you experience symptoms of vitamin D toxicity such as confusion, nausea, muscle weakness, or irregular heartbeat, call your provider right away.
When to take vitamin D3 (cholecalciferol) ?
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You can take vitamin D3 (cholecalciferol) at any time of the day. If your provider recommends you to take vitamin D3 (cholecalciferol) daily, it's best to take it at the same time every day so that the amount of vitamin D in your system stays consistent. If you're taking vitamin D3 (cholecalciferol) once a week, make sure to take it on the same day every week.
Do males and females need different amounts of vitamin D3 (cholecalciferol) ?
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No. The recommended dietary allowance (RDA) for vitamin D is the same for males and females, no matter the age.
Is vitamin D the same as vitamin D3?
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Yes, vitamin D3 (cholecalciferol) is a form of vitamin D. There are two main forms of vitamin D found in supplements and foods: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) . They're both considered "vitamin D" and differ slightly in their chemical structure.
What's the difference between vitamin D2 and D3?
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Both vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) are forms of vitamin D, and they're both used to treat low levels of vitamin D. However, research suggests that vitamin D3 (cholecalciferol) might work better. Another difference is that vitamin D2 (ergocalciferol) is typically made from plant sources, while vitamin D3 (cholecalciferol) often comes from animal sources. It's unlikely your provider would recommend taking both vitamin D2 and D3 at the same time, since they work similarly to raise vitamin D levels in your body. Also, taking too much vitamin D can lead to serious side effects.
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What are the risks and warnings for Vitamin D3 (cholecalciferol) ?
Vitamin D3 (cholecalciferol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
High calcium or vitamin D levels
Vitamin D3 (cholecalciferol) shouldn't be used if you have high levels of calcium or vitamin D in your blood. If you take more vitamin D3 (cholecalciferol) than the recommended or prescribed dose, it can cause calcium to build up in your blood. This can be dangerous for your kidneys. If you're taking vitamin D3 (cholecalciferol) to treat low vitamin D levels or other conditions diagnosed by your provider, be sure to get all ordered blood tests done on time. That way, your provider can make sure your vitamin D levels aren't too high and you're taking the correct dose. If you notice unexplained nausea that doesn't go away, a loss of appetite, weight loss, constipation, muscle pain, muscle stiffness, or a change in how much or how often you urinate, talk to your provider. These could be early signs that you're taking too much vitamin D and your calcium blood level is too high.
Vitamin D3 (cholecalciferol) dosage forms
Capsule
| Dosage | As low as |
|---|---|
| 1000iu | $4.10 for 5 capsules |
| 2000iu | $6.67 for 90 capsules |
| 5000iu | $5.77 for 90 capsules |
| 10000iu | $7.28 for 30 capsules |
| 50000iu | $9.66 for 12 capsules |
Tablet
| Dosage | As low as |
|---|---|
| 1000iu | $3.84 for 90 tablets |
| 2000iu | $5.12 for 90 tablets |
Typical dosing for Vitamin D3 (cholecalciferol)
Vitamin D3 (cholecalciferol) is taken by mouth. Your dose will depend on your individual needs. Ask your healthcare provider or pharmacist about what dose and how often you should take vitamin D3 (cholecalciferol) .
Vitamin D3 (cholecalciferol) comes in many different strengths. The dose of vitamin D3 (cholecalciferol) is measured in both micrograms (mcg) and international units (IU): 1 mcg vitamin D is equal to 40 IU.
The highest strength of vitamin D3 (cholecalciferol) is 1,250 mcg (which is 50,000 IU) and is typically reserved to treat very low vitamin D levels and certain related conditions.
More on Vitamin D3 (cholecalciferol) dosage forms
How much does Vitamin D3 (cholecalciferol) cost?
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Vitamin D3 (cholecalciferol) (generic)
Vitamin D3 (cholecalciferol) contraindications
Contraindications are specific health conditions or situations in which a person shouldnot take a medication due to safety concerns. If you have any of the following conditionsor if any of the following apply to you, let your healthcare provider know because Vitamin D3 (cholecalciferol) will not be safe for you to take.
High blood calcium levels
High blood vitamin D levels
Malabsorption syndrome (when your body can't absorb nutrients)
What are alternatives to Vitamin D3 (cholecalciferol) ?
There are a number of medications that your doctor can prescribe in place of Vitamin D3 (cholecalciferol) . Compare a few possible alternatives below.
Vitamin D3 (cholecalciferol)
Used for:
Low vitamin D levels
$9.66 Lowest GoodRx priceView Prices
Vitamin D2 (ergocalciferol)
Used for:
Hypoparathyroidism (low parathyroid hormone levels)
Familial hypophosphatemia (genetic condition causing low phosphate levels)
Vitamin D-resistant rickets (weakening of the bones caused by low vitamin D)
$7.57 Lowest GoodRx priceView Prices
What is the latest news about Vitamin D3 (cholecalciferol) ?
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References
starsBest studies we found
American Association of Clinical Endocrinologists. (2019). Vitamin D deficiency.
Centers for Disease Control and Prevention. (2022). Micronutrient facts.
Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. (2011). 3: Overview of vitamin D. Dietary Reference Intakes for Calcium and Vitamin D.
View All References (6)
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Marcinowska-Suchowierska, E., et al. (2018). Vitamin D toxicity-A clinical perspective. Frontiers in Endocrinology.
National Institutes of Health, Office of Dietary Supplements. (2022). Vitamin D: Fact sheet for consumers.
National Institutes of Health, Office of Dietary Supplements. (2023). Vitamin D: Fact sheet for health professionals.
People for the Ethical Treatment of Animals. (2015). 5 ways to increase your vitamin D intake.
Pharmin USA, LLC. (2017). Decalcitrol- cholecalciferol tablet, coated [package insert]. DailyMed.
Yyux Inc. (2020). Yyux organic liquid vitamin D3 drops 1000 IU- cholecalciferol solution/ drops [package insert]. DailyMed.
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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